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Self-insured employers are bigger companies with more resources that hire an insurer like Blue Cross to administer an insurance plan, but the employer assumes the risk of claims exceeding premiums

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While the mechanistic insights are encouraging, further clinical investigations are needed to isolate the direct analgesic effects of GLP-1R agonists from those mediated by weight loss

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The most important limitation on enthusiasm is safety: the dominant and consistent burden is gastrointestinal intolerance and delayed gastric emptying, which has practical implications for dose escalation and peri-procedural management (Jalleh et al., 2024), (Karagiannis et al., 2024)